Mild, asymptomatic COVID patients develop self-attacking antibodies after recovery: study

Coronavirus infection can cause an immune response that lasts long beyond the initial infection and recovery, or the symptoms are moderate or quiet, according to a new study published in the ‘Journal of Translational Medicine’. When a virus or other disease infects a person, their systems produce antibodies, which identify foreign objects and prevent them from invading cells.

Auto-antlers, on the other hand, are produced in some circumstances and can damage the body’s own organs and tissues over time. People previously infected with SARS-CoV-2, the virus that causes COVID-19, show a wide range of autoantibodies six months after they are fully recovered, according to Cedars-Sinai researchers.

Prior to this study, experts understood that severe cases of COVID-19 can overwork the immune system, resulting in the production of autoantibodies. This is the first study that shows not only the existence but also the maintenance of elevated autoantibodies after a mild or asymptomatic infection.

“These findings help to explain what makes COVID-19 a particularly unique disease. These patterns of immune regulation may underlie the various types of persistent symptoms we see in people who continue to develop the condition that it is now referred to as long COVID-19, “said a researcher, Justyna Fert-Bober, PhD, in the Department of Cardiology, at the Smidt Heart Institute. Justyna Fert-Bober is co-senior author of the study.

The Cedars-Sinai researchers collected 177 participants with conclusive evidence of a past SARS-CoV-2 infection for their research. Blood samples from these participants were compared with samples taken from healthy people before the pandemic. Autoantibodies were found to be increased in all patients who had evidence of SARS-CoV-2 infection, according to the study. Some autoantibodies are also found in people with disorders such as lupus and rheumatoid arthritis, in which the immune system targets its own healthy cells.

Men had a higher number of elevated autoantibodies than women

Some autoantibodies are associated with autoimmune diseases, which are more common in women than in men. Men, on the other hand, had a higher number of elevated autoantibodies than women in this study.

“On the one hand, this finding is paradoxical because autoimmune conditions are most prevalent in women. On the other hand, it is also somewhat expected to see everything we know about men who are more vulnerable to the most serious forms of COVID. -19 “, stated Fert-Bober.

The researchers want to expand the study to see what types of autoantibodies are present and remain in individuals who have long-term COVID-19 symptoms. Because this study looked at people who were infected before immunizations, researchers will see if autoantibodies are produced in the same way in people who get breakthrough infections.

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